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Gentest^®
ADMET Research Services

IND-enabling ADME studies to predict drug-drug interaction.

Discovery’s Gentest^® ADME Research Services have provided IND-enabling in vitro ADME and drug-drug interaction services for more than two decades.

When we test your drug candidate, we use our innovative, regulatory-aligned Gentest^® in vitro products, cell models, and methodologies. Your project will be led by an experienced study director, with reliable communication from the initial inquiry through to data analysis and a submission-quality report.

Gentest^® ADME Research Services Advantages

Enables IND applications with over 20 years of ADME service experience
Offers enzyme induction, enzyme inhibition, transporter interaction, reaction phenotyping, and custom services
Ensures client expectations are met on timelines, data quality, and report writing
Provides flexibility, open communication, and collaboration with our scientific staff
Utilizes Gentest^®’s innovative products, including:

Gentest^® Enzyme Induction Services

Testing for mRNA and enzyme activity for a comprehensive portfolio of inducible enzymes, including CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, UGTs and transporters

Gentest^® Enzyme Inhibition Services

In vitro inhibition testing for a range of drug metabolizing enzymes, including CYPs (reversible and TDI), UGTs, Oxidases (e.g., AO, MAO), and Esterases (e.g., CES, ChE)

Gentest^® Transporter Interaction Services

SLC transporter studies with Gentest TransportoCells™ model, P-gp/MRP/BCRP/BSEP vesicles studies, and Efflux studies with MDR1 LLC-PK1 and Caco-2 cell lines

Gentest^® Reaction Phenotyping Services

Comprehensive Phase I/II (CYP, UGT, AO/XO, FMO, CES, SULT) enzyme identification using Gentest Supersomes^®, human liver fractions and human hepatocytes, including enzyme kinetics (Km, CLint) and fm determination (selective chemical inhibition, RAF/ISEF scaling)

Gentest^® Custom Services

Customized ADME analyses for unusual drug metabolizing enzymes, custom expressions, extrahepatic tissues, and assay transfers.

Gentest® ADMET Research Services

Discovery’s Gentest® ADME Research Services have provided IND-enabling in vitro ADME and drug-drug interaction services for more than two decades.

Gentest® ADME Research Services Advantages

Gentest® Enzyme Induction Services

Gentest® Enzyme Inhibition Services

Gentest® Transporter Interaction Services

SLC transporter studies with Gentest TransportoCells™ model, P-gp/MRP/BCRP/BSEP vesicles studies, and Efflux studies with MDR1 LLC-PK1 and Caco-2 cell lines

Gentest® Reaction Phenotyping Services

Gentest® Custom Services

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April 2024

May 2024

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